报错截图如下：

解决方案：

Python38_32\Lib\site-packages\comtypes\__init__.py的CoCreateInstance()里添加CoInitialize()

下面代码中的倒数第3行

def CoCreateInstance(clsid, interface=None, clsctx=None, punkouter=None):
    """The basic windows api to create a COM class object and return a
    pointer to an interface.
    """
    if clsctx is None:
        clsctx = CLSCTX_SERVER
    if interface is None:
        interface = IUnknown
    p = POINTER(interface)()
    iid = interface._iid_
    CoInitialize()
    _ole32.CoCreateInstance(byref(clsid), punkouter, clsctx, byref(iid), byref(p))
    return p

参考： https://blog.csdn.net/wjx199112/article/details/121649643